Siliphos information and review of studies
This product is a milk thistle extract.
Surg Endosc. 2012.
Perioperative polyphenon E- and siliphos-inhibited colorectal tumor growth and metastases without impairment of gastric or abdominal wound healing in mouse models. Yan X, Gardner TR, Grieco M, Herath SA, Jang JH, Kirchoff D, Njoh L, Shantha Kumara HM, Naffouje S, Whelan RL. Colon & Rectum Surgery, St. Luke's Roosevelt Hospital Center, 432 West, 58th Street, Room 517, New York, NY, USA
A review of the bioavailability and clinical efficacy of milk thistle
phytosome: a silybin-phosphatidylcholine complex Siliphos.
Altern Med Rev. 2005.
Certain of the water-soluble flavonoid molecules can be converted into lipid-compatible molecular complexes, aptly called phytosomes. Phytosomes are better able to transition from a hydrophilic environment into the lipid-friendly environment of the outer cell membrane, and from there into the cell, finally reaching the blood. The fruit of the milk thistle plant (Silybum marianum, Family Asteraceae) contains flavonoids that are liver protectants. The standardized extract known as silymarin contains three flavonoids of the flavonol subclass. Silybin predominates, followed by silydianin and silychristin. Although silybin is the most potent of the flavonoids in milk thistle, similar to other flavonoids it is not well-absorbed. Silybin-phosphatidylcholine complexed as a phytosome provides significant liver protection and enhanced bioavailability over conventional silymarin.
Fetoprotectivity of the flavanolignan compound siliphos
against ethanol-induced toxicity.
Phytother Res. 2000; Edwards J, , Reyes E. New Mexico Highlands University, Las Vegas, NM, USA.
Of the three flavanolignans that are found in silymarin (Silybum marianum), silybin is thought to be the primary therapeutic constituent. To test the capacity of silybin to protect the rat fetus from toxic effects of maternally ingested EtOH we did the following: Adult female rats were assigned to one of four groups; EtOH, EtOH / silybin, pair-fed control, and chow fed control. Silybin was orally administered as Siliphos, which is one part silybin to two parts phosphatidylcholine. All groups except the chow-fed control were maintained on a liquid diet throughout pregnancy. On day 21 of pregnancy the rats were killed and the fetuses removed. Gamma glutamyl transpeptidase (GGTP) activity and glutathione (GSH) levels were determined for liver and brain tissue for both the fetuses and the dams. Maternal and fetal GGTP activity in the EtOH rats was significantly higher than that of pair-fed controls, whereas the GGTP activity observed in the Siliphos / EtOH rats was not elevated. Fetal mortality rates in the EtOH rats significantly exceeded those of all three other groups.